Ganzinger, MatthiasMatthiasGanzingerGlaab, EnricoEnricoGlaabKerssemakers, JulesJulesKerssemakersNahnsen, SvenSvenNahnsenSax, UlrichUlrichSaxSchaadt, Nadine SarahNadine SarahSchaadtSchapranow, Matthieu-P.Matthieu-P.SchapranowTiede, ThorstenThorstenTiedeWolkenhauer, Olaf2024-10-142024-10-142021http://www.sciencedirect.com/science/article/pii/B9780128012383116216https://knowledge.hpi.de/handle/123456789/3239Systems medicine is an interdisciplinary approach in medicine that relies on computational models based on data from a variety of sources. Typically, such sources include clinical and biomedical data with heterogeneous data definitions that are sometimes not even structured in a useful way. Consequently, the systematic management of data is an important element for the successful implementation of systems medicine in both research and clinical application. In this article, we provide an overview over the following selected aspects of data management:•Integration of multiple data sources•IT infrastructures•Data protection regulations•Data history and data quality•Data sharing/FAIR principles•Use and access policies The presented best practices and experiences result from several systems medicine projects in which the authors have participated. They can be considered as recommendations for future projects in order to quickly set up data management infrastructures for systems medicine.incollection